{"id":1456398,"date":"2026-04-08T04:30:00","date_gmt":"2026-04-08T08:30:00","guid":{"rendered":"https:\/\/www.statnews.com\/?p=1456398"},"modified":"2026-04-08T16:56:36","modified_gmt":"2026-04-08T20:56:36","slug":"duchenne-exon-skipping-breakthrough-one-mother-quest","status":"publish","type":"post","link":"https:\/\/www.statnews.com\/2026\/04\/08\/duchenne-exon-skipping-breakthrough-one-mother-quest\/","title":{"rendered":"A decade ago, these drugs tore apart the FDA. Today, they might be some patients&#8217; best hope"},"content":{"rendered":"<p class=\"has-drop-cap\">A year after the worst day of her life, Debra Miller received a voicemail she couldn\u2019t quite make out. In a thick accent, a man said something about research and left a phone number. She called but couldn\u2019t get through. \u201cI didn\u2019t know what country code to put in,\u201d she said.<\/p>\n\n\n\n<p>Debra moved on, but the voice kept tumbling through her brain. She was desperate. Her first child, Hawken, had been diagnosed 13 months before with Duchenne muscular dystrophy. In blunt tones she would never forget, a doctor had told her that her 5-year-old boy would slowly lose the ability to walk and die by 18.<\/p>\n\n\n\n<p>When she finally figured out the digits, a Dutch scientist explained he was launching a startup around one of the most counterintuitive ideas in modern genetics: that sometimes you can fix a broken gene by breaking it just a little bit more.\u00a0<\/p>\n\n\n\n<p>That strategy, known as exon skipping, would taunt Debra for two decades, always promising a therapy just out of reach. It prompted her to raise $1.3 million for the Dutch scientist and helped turn her fledgling advocacy group, CureDuchenne, into a powerhouse. Eventually, the idea spread far beyond the Netherlands and Debra\u2019s home in Newport Beach, Calif., stirring tenuous\u00a0hope for a life-altering treatment.\u00a0<\/p>\n\n\n\n<p>Exon-skipping drugs sparked a civil war within the Food and Drug Administration. Under pressure from advocates and companies, a top official overrode reviewers to approve the first of several candidates. One company, Sarepta Therapeutics, has since earned over $5.5 billion from drugs that may or may not provide much benefit.\u00a0<\/p>\n\n\n\n<p>Throughout, by the fickle winds of scientific misfortune, mother and son remained waiting \u2014 until about two and a half years ago. That\u2019s when Hawken enrolled in a clinical trial for a new exon-skipping drug Debra helped support. <a href=\"https:\/\/investors.aviditybiosciences.com\/2025-09-10-Avidity-Biosciences-Del-zota-Demonstrated-Reversal-of-Disease-Progression-Across-Key-Functional-Endpoints-in-EXPLORE44-R-and-EXPLORE44-OLE-TM-Phase-1-2-Trial-in-People-Living-with-DMD44\" target=\"_blank\" rel=\"noopener\">The results from him and 38 other patients<\/a> have since stunned some of the field\u2019s top experts.\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>A mother&#8217;s persistence helps revive an all-but-abandoned drug class and could aid her son and thousands of others with neuromuscular conditions.<\/p>\n","protected":false},"author":676,"featured_media":1457094,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-photo-essay-50-50","format":"standard","meta":{"stat_display_restriction_not_latest":false,"stat_featured_image_caption":"Hawken Miller at his home in Newport Beach, Calif.","stat_featured_image_nocrop":false,"stat_featured_image_focal_point":{"x":0.44,"y":0.42},"stat_article_wordmark_img":[],"stat_article_wordmark_url":"","stat_article_wordmark_height":"125px","stat_article_wordmark_enable":false,"stat_article_subheadline":"Once-divisive 'exon-skipping' treatments for Duchenne muscular dystrophy are showing startling promise\u00a0","stat_paywall_restrict":true,"footnotes":"","stat_article_enhanced_byline":"Mast, who has reported extensively on rare diseases for four years, spoke with Debra and Hawken Miller more than six times over the last eight months and interviewed more than a dozen other advocates, researchers, executives, and former FDA officials for this story.","stat_article_newsletter_id":"","stat_article_header_color_scheme":"","_yoast_wpseo_primary_category":1860,"stat_paywall_move_flag":0},"categories":[3292,51,1860],"tags":[2655,1246,294,209134,1773,651,5311,789,5393],"authors":[202907],"class_list":["post-1456398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotech","category-in-the-lab","category-special-report","tag-biotechnology","tag-drug-development","tag-fda","tag-gene-editing","tag-gene-therapy","tag-patients","tag-rare-diseases","tag-research","tag-stat-plus"],"featured_image_src":"https:\/\/www.statnews.com\/wp-content\/uploads\/2026\/04\/CureDuchenne_001-1024x1368.jpg","coauthors":[{"avatar":"<img width=\"80\" height=\"80\" src=\"https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-80x80.png\" class=\"avatar\" alt=\"Jason Mast\" loading=\"lazy\" sizes=\"auto, (min-width: 625px) and (max-width: 767px) 719px, (min-width: 768px) and (max-width: 899px) 835px, (min-width: 900px) and (max-width: 1023px) 635px, (min-width: 1024px) and (max-width: 1199px) 803px, (min-width: 1200px) and (max-width: 1439px) 994px, (min-width: 1440px) 982px, 576px\" decoding=\"async\" srcset=\"https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-80x80.png 80w, https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-328x328.png 328w, https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-500x500.png 500w, https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-576x576.png 576w, https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round-160x160.png 160w, https:\/\/www.statnews.com\/wp-content\/uploads\/2022\/05\/jason-mast-avatar-round.png 600w\" \/>","display_name":"Jason Mast","author_page":"https:\/\/www.statnews.com\/staff\/jason-mast\/","first_name":"Jason","title":"General Assignment Reporter","bio":"Jason Mast is a general assignment reporter at STAT focused on the science behind new medicines and the systems and people that decide whether that science ever reaches patients. You can reach Jason on Signal at JasonMast.05.","email_address":"jason.mast@statnews.com","email_url":"mailto:jason.mast@statnews.com","twitter_url":"https:\/\/x.com\/JasonMMast","twitter_handle":"@JasonMMast","facebook_url":"","linkedin_url":"","web_url":"","bluesky_url":"","bluesky_handle":""}],"stat_card_curation":{"image_id":0,"title":"","excerpt":"Once-divisive 'exon-skipping' treatments for Duchenne muscular dystrophy are showing startling promise","video_id":0,"disable_topic_image_curation":false},"template_inline_styles":{"global_styles":":root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4\/3;--wp--preset--aspect-ratio--3-4: 3\/4;--wp--preset--aspect-ratio--3-2: 3\/2;--wp--preset--aspect-ratio--2-3: 2\/3;--wp--preset--aspect-ratio--16-9: 16\/9;--wp--preset--aspect-ratio--9-16: 9\/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #FFFFFF;--wp--preset--color--pale-pink: 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!important;}.has-grey-20-color{color: var(--wp--preset--color--grey-20) !important;}.has-beige-70-color{color: var(--wp--preset--color--beige-70) !important;}.has-beige-60-color{color: var(--wp--preset--color--beige-60) !important;}.has-beige-50-color{color: var(--wp--preset--color--beige-50) !important;}.has-beige-40-color{color: var(--wp--preset--color--beige-40) !important;}.has-beige-30-color{color: var(--wp--preset--color--beige-30) !important;}.has-beige-20-color{color: var(--wp--preset--color--beige-20) !important;}.has-beige-10-color{color: var(--wp--preset--color--beige-10) !important;}.has-gold-70-color{color: var(--wp--preset--color--gold-70) !important;}.has-gold-60-color{color: var(--wp--preset--color--gold-60) !important;}.has-gold-50-color{color: var(--wp--preset--color--gold-50) !important;}.has-gold-40-color{color: var(--wp--preset--color--gold-40) !important;}.has-gold-30-color{color: var(--wp--preset--color--gold-30) !important;}.has-gold-20-color{color: var(--wp--preset--color--gold-20) !important;}.has-gold-10-color{color: var(--wp--preset--color--gold-10) !important;}.has-skin-70-color{color: var(--wp--preset--color--skin-70) !important;}.has-skin-60-color{color: var(--wp--preset--color--skin-60) !important;}.has-skin-50-color{color: var(--wp--preset--color--skin-50) !important;}.has-skin-40-color{color: var(--wp--preset--color--skin-40) !important;}.has-skin-30-color{color: var(--wp--preset--color--skin-30) !important;}.has-skin-20-color{color: var(--wp--preset--color--skin-20) !important;}.has-skin-10-color{color: var(--wp--preset--color--skin-10) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-teal-50-background-color{background-color: var(--wp--preset--color--teal-50) !important;}.has-grey-10-background-color{background-color: var(--wp--preset--color--grey-10) !important;}.has-grey-80-background-color{background-color: var(--wp--preset--color--grey-80) !important;}.has-grey-40-background-color{background-color: var(--wp--preset--color--grey-40) !important;}.has-teal-10-background-color{background-color: var(--wp--preset--color--teal-10) !important;}.has-blue-70-background-color{background-color: var(--wp--preset--color--blue-70) !important;}.has-blue-60-background-color{background-color: var(--wp--preset--color--blue-60) !important;}.has-blue-50-background-color{background-color: var(--wp--preset--color--blue-50) !important;}.has-blue-40-background-color{background-color: var(--wp--preset--color--blue-40) !important;}.has-blue-30-background-color{background-color: var(--wp--preset--color--blue-30) !important;}.has-blue-20-background-color{background-color: var(--wp--preset--color--blue-20) !important;}.has-blue-10-background-color{background-color: var(--wp--preset--color--blue-10) !important;}.has-teal-70-background-color{background-color: var(--wp--preset--color--teal-70) !important;}.has-teal-60-background-color{background-color: var(--wp--preset--color--teal-60) !important;}.has-teal-40-background-color{background-color: var(--wp--preset--color--teal-40) !important;}.has-teal-30-background-color{background-color: var(--wp--preset--color--teal-30) !important;}.has-teal-20-background-color{background-color: var(--wp--preset--color--teal-20) !important;}.has-forest-70-background-color{background-color: var(--wp--preset--color--forest-70) !important;}.has-forest-60-background-color{background-color: var(--wp--preset--color--forest-60) !important;}.has-forest-50-background-color{background-color: var(--wp--preset--color--forest-50) !important;}.has-forest-40-background-color{background-color: var(--wp--preset--color--forest-40) !important;}.has-forest-30-background-color{background-color: var(--wp--preset--color--forest-30) !important;}.has-forest-20-background-color{background-color: var(--wp--preset--color--forest-20) !important;}.has-forest-10-background-color{background-color: var(--wp--preset--color--forest-10) !important;}.has-green-70-background-color{background-color: var(--wp--preset--color--green-70) !important;}.has-green-60-background-color{background-color: var(--wp--preset--color--green-60) !important;}.has-green-50-background-color{background-color: var(--wp--preset--color--green-50) !important;}.has-green-40-background-color{background-color: var(--wp--preset--color--green-40) !important;}.has-green-30-background-color{background-color: var(--wp--preset--color--green-30) !important;}.has-green-20-background-color{background-color: var(--wp--preset--color--green-20) !important;}.has-green-10-background-color{background-color: var(--wp--preset--color--green-10) !important;}.has-lime-70-background-color{background-color: var(--wp--preset--color--lime-70) !important;}.has-lime-60-background-color{background-color: var(--wp--preset--color--lime-60) !important;}.has-lime-50-background-color{background-color: var(--wp--preset--color--lime-50) !important;}.has-lime-40-background-color{background-color: var(--wp--preset--color--lime-40) !important;}.has-lime-30-background-color{background-color: var(--wp--preset--color--lime-30) !important;}.has-lime-20-background-color{background-color: var(--wp--preset--color--lime-20) !important;}.has-lime-10-background-color{background-color: var(--wp--preset--color--lime-10) !important;}.has-yellow-70-background-color{background-color: var(--wp--preset--color--yellow-70) !important;}.has-yellow-60-background-color{background-color: var(--wp--preset--color--yellow-60) !important;}.has-yellow-50-background-color{background-color: var(--wp--preset--color--yellow-50) !important;}.has-yellow-40-background-color{background-color: var(--wp--preset--color--yellow-40) !important;}.has-yellow-30-background-color{background-color: var(--wp--preset--color--yellow-30) !important;}.has-yellow-20-background-color{background-color: var(--wp--preset--color--yellow-20) !important;}.has-yellow-10-background-color{background-color: var(--wp--preset--color--yellow-10) !important;}.has-peach-70-background-color{background-color: var(--wp--preset--color--peach-70) !important;}.has-peach-60-background-color{background-color: var(--wp--preset--color--peach-60) !important;}.has-peach-50-background-color{background-color: var(--wp--preset--color--peach-50) !important;}.has-peach-40-background-color{background-color: var(--wp--preset--color--peach-40) !important;}.has-peach-30-background-color{background-color: var(--wp--preset--color--peach-30) !important;}.has-peach-20-background-color{background-color: var(--wp--preset--color--peach-20) !important;}.has-peach-10-background-color{background-color: var(--wp--preset--color--peach-10) !important;}.has-plum-70-background-color{background-color: var(--wp--preset--color--plum-70) !important;}.has-plum-60-background-color{background-color: var(--wp--preset--color--plum-60) !important;}.has-plum-50-background-color{background-color: var(--wp--preset--color--plum-50) !important;}.has-plum-40-background-color{background-color: var(--wp--preset--color--plum-40) !important;}.has-plum-30-background-color{background-color: var(--wp--preset--color--plum-30) !important;}.has-plum-20-background-color{background-color: var(--wp--preset--color--plum-20) !important;}.has-plum-10-background-color{background-color: var(--wp--preset--color--plum-10) !important;}.has-grey-70-background-color{background-color: var(--wp--preset--color--grey-70) !important;}.has-grey-60-background-color{background-color: var(--wp--preset--color--grey-60) !important;}.has-grey-50-background-color{background-color: var(--wp--preset--color--grey-50) !important;}.has-grey-30-background-color{background-color: var(--wp--preset--color--grey-30) !important;}.has-grey-20-background-color{background-color: var(--wp--preset--color--grey-20) !important;}.has-beige-70-background-color{background-color: var(--wp--preset--color--beige-70) !important;}.has-beige-60-background-color{background-color: var(--wp--preset--color--beige-60) !important;}.has-beige-50-background-color{background-color: var(--wp--preset--color--beige-50) !important;}.has-beige-40-background-color{background-color: var(--wp--preset--color--beige-40) !important;}.has-beige-30-background-color{background-color: var(--wp--preset--color--beige-30) !important;}.has-beige-20-background-color{background-color: var(--wp--preset--color--beige-20) !important;}.has-beige-10-background-color{background-color: var(--wp--preset--color--beige-10) !important;}.has-gold-70-background-color{background-color: var(--wp--preset--color--gold-70) !important;}.has-gold-60-background-color{background-color: var(--wp--preset--color--gold-60) !important;}.has-gold-50-background-color{background-color: var(--wp--preset--color--gold-50) !important;}.has-gold-40-background-color{background-color: var(--wp--preset--color--gold-40) !important;}.has-gold-30-background-color{background-color: var(--wp--preset--color--gold-30) !important;}.has-gold-20-background-color{background-color: var(--wp--preset--color--gold-20) !important;}.has-gold-10-background-color{background-color: var(--wp--preset--color--gold-10) !important;}.has-skin-70-background-color{background-color: var(--wp--preset--color--skin-70) !important;}.has-skin-60-background-color{background-color: var(--wp--preset--color--skin-60) !important;}.has-skin-50-background-color{background-color: var(--wp--preset--color--skin-50) !important;}.has-skin-40-background-color{background-color: var(--wp--preset--color--skin-40) !important;}.has-skin-30-background-color{background-color: var(--wp--preset--color--skin-30) !important;}.has-skin-20-background-color{background-color: var(--wp--preset--color--skin-20) !important;}.has-skin-10-background-color{background-color: var(--wp--preset--color--skin-10) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-teal-50-border-color{border-color: var(--wp--preset--color--teal-50) !important;}.has-grey-10-border-color{border-color: var(--wp--preset--color--grey-10) !important;}.has-grey-80-border-color{border-color: var(--wp--preset--color--grey-80) !important;}.has-grey-40-border-color{border-color: var(--wp--preset--color--grey-40) !important;}.has-teal-10-border-color{border-color: var(--wp--preset--color--teal-10) !important;}.has-blue-70-border-color{border-color: var(--wp--preset--color--blue-70) !important;}.has-blue-60-border-color{border-color: var(--wp--preset--color--blue-60) !important;}.has-blue-50-border-color{border-color: var(--wp--preset--color--blue-50) !important;}.has-blue-40-border-color{border-color: var(--wp--preset--color--blue-40) !important;}.has-blue-30-border-color{border-color: var(--wp--preset--color--blue-30) !important;}.has-blue-20-border-color{border-color: var(--wp--preset--color--blue-20) !important;}.has-blue-10-border-color{border-color: var(--wp--preset--color--blue-10) !important;}.has-teal-70-border-color{border-color: var(--wp--preset--color--teal-70) !important;}.has-teal-60-border-color{border-color: var(--wp--preset--color--teal-60) !important;}.has-teal-40-border-color{border-color: var(--wp--preset--color--teal-40) !important;}.has-teal-30-border-color{border-color: var(--wp--preset--color--teal-30) !important;}.has-teal-20-border-color{border-color: var(--wp--preset--color--teal-20) !important;}.has-forest-70-border-color{border-color: var(--wp--preset--color--forest-70) !important;}.has-forest-60-border-color{border-color: var(--wp--preset--color--forest-60) !important;}.has-forest-50-border-color{border-color: var(--wp--preset--color--forest-50) !important;}.has-forest-40-border-color{border-color: var(--wp--preset--color--forest-40) !important;}.has-forest-30-border-color{border-color: var(--wp--preset--color--forest-30) !important;}.has-forest-20-border-color{border-color: var(--wp--preset--color--forest-20) !important;}.has-forest-10-border-color{border-color: var(--wp--preset--color--forest-10) !important;}.has-green-70-border-color{border-color: var(--wp--preset--color--green-70) !important;}.has-green-60-border-color{border-color: var(--wp--preset--color--green-60) !important;}.has-green-50-border-color{border-color: var(--wp--preset--color--green-50) !important;}.has-green-40-border-color{border-color: var(--wp--preset--color--green-40) !important;}.has-green-30-border-color{border-color: var(--wp--preset--color--green-30) !important;}.has-green-20-border-color{border-color: var(--wp--preset--color--green-20) !important;}.has-green-10-border-color{border-color: var(--wp--preset--color--green-10) !important;}.has-lime-70-border-color{border-color: var(--wp--preset--color--lime-70) !important;}.has-lime-60-border-color{border-color: var(--wp--preset--color--lime-60) !important;}.has-lime-50-border-color{border-color: var(--wp--preset--color--lime-50) !important;}.has-lime-40-border-color{border-color: var(--wp--preset--color--lime-40) !important;}.has-lime-30-border-color{border-color: var(--wp--preset--color--lime-30) !important;}.has-lime-20-border-color{border-color: var(--wp--preset--color--lime-20) !important;}.has-lime-10-border-color{border-color: var(--wp--preset--color--lime-10) !important;}.has-yellow-70-border-color{border-color: var(--wp--preset--color--yellow-70) !important;}.has-yellow-60-border-color{border-color: var(--wp--preset--color--yellow-60) !important;}.has-yellow-50-border-color{border-color: var(--wp--preset--color--yellow-50) !important;}.has-yellow-40-border-color{border-color: var(--wp--preset--color--yellow-40) !important;}.has-yellow-30-border-color{border-color: var(--wp--preset--color--yellow-30) !important;}.has-yellow-20-border-color{border-color: var(--wp--preset--color--yellow-20) !important;}.has-yellow-10-border-color{border-color: var(--wp--preset--color--yellow-10) !important;}.has-peach-70-border-color{border-color: var(--wp--preset--color--peach-70) !important;}.has-peach-60-border-color{border-color: var(--wp--preset--color--peach-60) !important;}.has-peach-50-border-color{border-color: var(--wp--preset--color--peach-50) !important;}.has-peach-40-border-color{border-color: var(--wp--preset--color--peach-40) !important;}.has-peach-30-border-color{border-color: var(--wp--preset--color--peach-30) !important;}.has-peach-20-border-color{border-color: var(--wp--preset--color--peach-20) !important;}.has-peach-10-border-color{border-color: var(--wp--preset--color--peach-10) !important;}.has-plum-70-border-color{border-color: var(--wp--preset--color--plum-70) !important;}.has-plum-60-border-color{border-color: var(--wp--preset--color--plum-60) !important;}.has-plum-50-border-color{border-color: var(--wp--preset--color--plum-50) !important;}.has-plum-40-border-color{border-color: var(--wp--preset--color--plum-40) !important;}.has-plum-30-border-color{border-color: var(--wp--preset--color--plum-30) !important;}.has-plum-20-border-color{border-color: var(--wp--preset--color--plum-20) !important;}.has-plum-10-border-color{border-color: var(--wp--preset--color--plum-10) !important;}.has-grey-70-border-color{border-color: var(--wp--preset--color--grey-70) !important;}.has-grey-60-border-color{border-color: var(--wp--preset--color--grey-60) !important;}.has-grey-50-border-color{border-color: var(--wp--preset--color--grey-50) !important;}.has-grey-30-border-color{border-color: var(--wp--preset--color--grey-30) !important;}.has-grey-20-border-color{border-color: 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