DOVER, N.H. — Not long after he woke from surgery in June, Bill Stewart made a pact with his newest organ. He wasn’t sure how long the thing would last. The doctors had been up-front from the get-go: It could be three months or six, one year or four. Still, the uncertainty hit him as he started getting back preliminary lab results, which were okay but left room for improvement. “My pig kidney and I had a little conversation while I was laying there. I just basically said, ‘I’m going to do everything I can to make sure that you stay healthy, and I appreciate you doing everything you can to keep me upright and breathing,” Stewart said.
It’s been almost three months, and Stewart is home, back to work, and has even been able to go e-biking on a lakeside trail with his wife, blessedly untethered to the grueling schedules of dialysis for the first time in years, all thanks to a gene-edited Yucatan miniature pig named Lavender.
Stewart is the most recent recipient of a pig kidney — but chances are, he won’t hold that distinction for long. On Monday, eGenesis, a Cambridge-based biotechnology company, announced that it had been cleared by the Food and Drug Administration to begin a trial of kidneys from donor pigs that have been CRISPR’d to make their organs more human-friendly. Now, Massachusetts researchers will be performing more surgeries like Stewart’s to see whether these animal parts could serve as a lifeline for people with end-stage renal disease.
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